Marble Burying Test Interpretation

Regardless the test is widely applied to.

Marble burying test interpretation.

This test has some predictive value for anti depressant and or anxiolytic drugs. The marble burying test is used to record the number of marbles buried by mice placed in a novel environment. Mice which are placed individually in a cage bury glass marbles that are present in the cage. While widely used there is significant controversy over the interpretation of its results.

It has been shown to be sensitive to benzodiazepines as these compounds reduce burying behaviour when. It can be weeks before a noticeable change is observed in patients. However the test responds variably to a range of pharmacological interventions and little consensus exists regarding specific methodologies for its execution. The marble burying task can be used both as an indicator of obsessive compulsive like ocd behavior and or anxiety like behavior.

The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar. The marble burying test is commonly used to quantify anxiety obsessive compulsive or repetitive behaviour in rodents 1 3 performance on the marble burying test is also associated with general digging behaviour 4 7 and so the underlying construct being measured is still unclear regardless the typical protocol places 10 25 marbles in a cage containing sawdust or similar material. There is also a genetic component to. Rodent marble burying behavior in the marble burying test mbt is employed as a model or measure to study anxiety and compulsive like behaviors or anxiolytic and anticompulsive drug action.

Marble burying is an animal model used in scientific research to depict anxiety or obsessive compulsive disorder ocd behavior. It is based on the observation that rats and mice will bury either harmful or harmless objects in their bedding. It has also been proposed that the test may have predictive validity for the screening of novel antidepressants 12 15 anxiolytics 15 16 and antipsychotics 17 19. Marble burying the marble burying test is a useful model of neophobia 1 anxiety 1 7 and obsessive compulsive behavior 8 11.

Mice with ocd like symptoms tend to engage in a high degree of repetitive behaviors including digging. The marble burying test measures one acute dose of anti anxiety agent for thirty minutes. Therefore the test serves largely as a measure.