Marble Burying Test Wiki

Marbles are placed evenly onto the walls of an empty cage.

Marble burying test wiki.

Thus the general consensus is to perform a battery of anxiety tests with a high predictive validity to determine the potential therapeutic value of a novel agent. The mouse is treated with the vehicle or compound 30 minutes before the test. We tested the possibility that a genetic component underlies marble burying in mice and if there is a genetic correlation with other anxiety like traits. Gene editing eases the frantic burying of marbles bottom right in a mouse model of fragile x syndrome bottom left.

Following the last baseline behavioral screen the bedding material of the 18 n and the 18 h animals was exchanged with sawdust. However some investigators incorporate the sub acute treatment regimen as an essential component for screening anti compulsive agents. The animal is then placed in the cage containing the marbles. In the present investigation the mb test was applied as previously described broekkamp et al 1986 with respect to the setup for a one zone paradigm with slight modifications.

There is also a genetic component to this test. An increasing number of investigators utilize the marble burying assay despite the paucity of information available regarding what underlies the behavior. The marble burying behavior test is an acute test. Marble burying behavior gauges the level of anxiety in a mouse when it encounters unfamiliar objects.

The marble burying test measures one acute dose of anti anxiety agent for thirty minutes. Of duration of marbles buried test s mean sem time of nonmarble side s mean sem time nonmarble side 300 600 1800 4 2 2 0 7 3 0 9 8 4 0 4 143 4 292 30 916 45 47 ns 49 ns 51 ns data from 10 female. The validity of the marble burying test is quite controversial. It can be weeks before a noticeable change is observed in patients.

Since findings reported in the literature indicate that marble burying behavior. Disease head injury genetic modifications and treatment of mice with drugs can have profound effects on behavior. This test is used for evaluation of anxiolytic effect of a. Table 3 marble burying behavior in a two compartment box no.

Some strains show decreased burying behaviour. Zimeldine 10 0 mg kg reduced marble burying without affecting locomotor activity. This can be counteracted by coating marbles with substances such as tabasco sauce which will. Marble burying test is one of the models for evaluation of psychotropic and neurotropic activity.